Take this medication by mouth as directed by your doctor, usually once daily. Pick a time of day that is easy for you to remember, and take your pill at the same time each day. If you are taking the chewable tablet, you may either swallow it whole or chew it thoroughly and swallow. Tri-Sprintec (norgestimate and ethinyl estradiol) is a combination of the female hormones estrogen and progesterone used as contraception to prevent pregnancy. Tri- Sprintec is also used to treat severe acne. Unlike the combined birth control pills of norgestimate with ethinylestradiol, the combination of norgestimate with estradiol, sold under the brand name Prefest for menopausal hormone therapy, is reportedly only marketed in the United States and Brazil. Norgestimate and Ethinyl Estradiol Tablets: Take the first blue active pill of the first pack on the Sunday after your period starts, even if you are still bleeding. Norgestimate is a progestin that suppresses ovulation for contraception and reduces free testosterone to treat moderate acne vulgaris. The therapeutic index is wide as overdoses are rare. What is this medication? NORGESTIMATE; ETHINYL ESTRADIOL (nor JES ti mate; ETH in il es tra DYE ole) prevents ovulation and pregnancy. It may also be used to treat acne. It belongs to a group of medications called oral contraceptives. It is a combination of the hormones estrogen and progestin. It is a birth control pill that contains two types of hormones, ethinyl estradiol and norgestimate, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization (pregnancy) is prevented. Ethinyl estradiol and norgestimate: side effects, dosage, interactions, FAQs, reviews. Used for: abnormal uterine bleeding, acne, birth control, endometriosis, and more. Overview: Norgestimate/ethinyl estradiol is a birth control pill used to help prevent pregnancy in women. Common side effects include headache, nausea and vomiting, breast discomfort, irregular. Norgestimate and Ethinyl Estradiol package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.